Can I buy a ticket with two different forms of payment?

Yes, the airlines do permit two different forms of payment for one ticket if you book with an agent. Split payments cannot be done online. As this is a more complex transaction resulting in twice the work, many travel agencies and travel management companies will not handle this or will charge a higher fee to do so. Travelers contemplating this sort of split payment may want to examine their credit card insurance coverage carefully as many times the ticket will not be covered unless it is fully charged to one card.